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KMID : 0369820070370020119
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Jorunal of Korean Pharmaceutical Sciences
2007 Volume.37 No. 2 p.119 ~ p.126
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Analysis of Prescriptions for Oral Solid Dosage Forms Split at Primary Health Care Using National Health Insurance Database
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Park Se-Jung
Lee Suk-Hyang
Lee Eui-Kyung
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Abstract
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Tablet splitting is used in pharmacy practice to adjust the dose to be administered. However, it also causes several problems such as undesirable effect for sustained release or enteric-coated dosage form, inaccuracy of dose, and pharmacist’’s safety by splitting hazardous drugs. This study investigated the current status of oral dosage form splitting for patients older than 19 years by analyzing Korea National Health Insurance Claims Database. Out of oral solid drugs prescribed (N=1,486,584) 9.8% of them included tablets (or capsules) split. There were some splitting cases even in sustained release (4.9%), enteric-coated forms (1.3%) and hazardous drugs (2.7%) that were selected by NIOSH (The National Institute for Occupational Safety and Health). The most frequently split drugs were antihistamines, neuropsychotics and steroids. In case of digoxin and warfarin, unit doses in a domestic market were not diverse compared to foreign markets. Guidelines for splitting oral solid dosage forms, approval of diverse doses and conducting dose-response studies for the commonly splitting ingredients on Korean people are needed for the saff and effective use of oral solid drugs.
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KEYWORD
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Tablet splitting, Capsule splitting, Oral dosage form, Enteric-coated form
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